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Heather Powell

  • Associate Professor, Materials Science Engineering
  • Associate Professor, Biomedical Engineering
  • 2041 College Road
    Columbus, OH 43210
  • 614-247-8673

Honors

  • 2013

    Lumley Research Award. .

  • 2012

    Distinguished Undergraduate Research Mentor Award. .

  • 2012

    Herman Weed Award for Distinguished Teaching. .

  • 2004-2008

    Shriner's Hospitals for Children Post-Doctoral Research Fellowship. .

  • 2008

    Ralph E. Powe Junior Faculty Enhancement Award. .

  • 2001-2004

    National Defense Science amd Engineering Graduate Fellowship. .

  • 2000-2001

    University Fellow, The Ohio State University. .

  • 1999

    National Association of Geoscience Teachers Field Camp Award. .

  • 1999

    Materials Research Society: Undergraduate Materials Research Initiative Proposal Funded. .

Books

2010

  • Powell, H.M., Lannutti, J.J., Kniss, D.A.. 2010. "Nanoscalar Modifications to Tissue Engineering Polymers: Physical Control of Cell Behavior." Berlin: VDM Publishing Ltd..

Chapters

2012

  • Powell, H.M., Boyce, S.T.. 2012. "Tissue Engineering of Skin." In An Introduction to Biomaterials, 624 - Boca Raton: CRC Press.

2011

  • Powell, H.M., Armour, A.D., Boyce, S.T.. 2011. "Fluorescein diacetate for determination of cell viability in three-dimensional tissue engineered constructs." In Mammalian Cell Viability, edited by Martin Stoddart, New York: Springer Publishing Co..

2009

  • Powell, H.M., Boyce, S.T.. 2009. "Cultured Skin Substitutes." In Biomaterials for Treating Skin Loss, edited by D. Orgill and C. Butler, 183 - 206. Boca Raton: Woodhead Publishing Ltd..

Journal Articles

2013

  • Willard, J.J., Drexler, J.W., Das, A., Roy, S., Shilo, S., Shoseyov, O.,Powell, H.M., 2013, "Plant-Derived Human Recombinant Collagen Scaffolds for Tissue Engineering." Tissue Engineering Part A 19, no. 13-14, 1507 - 1518.
  • Christoforidis, J.B., Wang, J., Jiang, A., Willard, J., Pratt, C., Abdel-Rasoul, M., Roy, S., Powell, H.M., 2013, "The effect of intravitreal bevacizumab and ranibizumab on cutaneous tensile strength during wound healing.." Clinical Ophthalmology 7, 185 - 191.

2012

  • Blackstone, B.N., Powell, H.M., 2012, "Morphogenesis and Biomechanics of Engineered Skin Cultured Under Uniaxial Strain." Advances in Wound Care 1, no. 1/2, 69 - 74.
  • Blackstone, B.N., Willard, J.J., Nelson, M.T., Hart, R.T., Lannutti, J.J., Powell, H.M., 2012, "Plasma surface modification of electrospun fibers for adhesion-based cancer cell sorting." Integrative Biology 4, no. 9, 1112 - 1121.
  • Ebersole, G.C., Paranjape, H., Anderson, P.M., Powell, H.M., 2012, "Influence of hydration on fiber geometry in electrospun scaffolds." Acta Biomaterialia 8, no. 12, 4342 - 4348.
  • Blackstone, B.N., Wolever, J.D., and H.M. Powell, 2012, "Structural Alterations in Scaffold Architecture in Response to Mechanical Stimuli." Journal of Tissue Science and Engineering 3, no. 4, 122 -
  • Lee, C.H., Lim Y.C., Powell, H.M., Farson, D.F., Lannutti, J.J, 2012, "Electrospun Vascular Graft Properties Following Femtosecond Laser Ablation." Journal of Applied Polymer Science 124, no. 3, 2513 - 2523.

2011

  • Powell,H,M; Blackstone,B,N; Biswas,S; Roy,S; Sen,C,K, 2011, "REGULATION OF SKIN BIOMECHANICS VIA MICRORNA." WOUND REPAIR AND REGENERATION 19, no. 2, A43 - A43.
  • Lee, C.H., Lim Y.C., Farson, D.F., Powell, H.M., Lannutti, J.J., 2011, "Vascular Wall Engineering Via Femtosecond Laser Ablation: Scaffolds with Self-Containing Smooth Muscle Cell Populations." Annals of Biomedical Engineering 39, no. 12, 3031 - 3041.
  • Powell,Heather,M; Armour,Alexis,D; Boyce,Steven,T, 2011, "Fluorescein diacetate for determination of cell viability in 3D fibroblast-collagen-GAG constructs.." Methods in molecular biology (Clifton, N.J.) 740, 115 - 126.
  • Drexler, J.W., Powell, H.M., 2011, "Regulation of electrospun scaffold stiffness via coaxial core diameter.." Acta Biomaterialia 7, no. 3, 1133 - 1139.
  • Drexler, J.W., Powell, H.M., 2011, "DHT Crosslinking of Electrospun Collagen." Tissue Engineering Part C 17, no. 1, 9 - 17.

2010

  • Powell, H.M., K.L. McFarland, D.L. Butler, D.M. Supp and S.T. Boyce, 2010, "Uniaxial strain regulates gene expression, morphogenesis and tissue strength in engineered skin." Tissue Engineering A 16, no. 3, 1083 - 1092.
  • Kinneberg, K.R.C., Nirmalanandhan, V.S., Juncosa-Melvin, N., Powell, H.M., Boyce, S.T., Shearn, J.T., Butler, D.L., 2010, "Chondroitin-6-Sulfate Incorporation and Mechanical Stimulation Increase MSC-Collagen Sponge Construct Stiffness." Journal of Orthopaedic Research 28, no. 8, 1092 - 1099.
  • Ebersole, G.C., Anderson, P.M., Powell, H.M., 2010, "Epidermal Differentiation Governs Engineered Skin Biomechanics." Journal of Biomechanics 16, no. 43, 3183 - 3190.
  • Gundersen, S.I., Chen, G., Powell, H.M., Palmer, A.F., 2010, "Hemoglobin regulates the metabolic and synthetic function of rat insulinoma cells cultured in a hollow fiber bioreactor." Biotechnology and Bioengineering 3, no. 107, 582 - 592.

2009

  • Powell, H.M, Boyce, S.T., 2009, "Engineered Human Skin Fabricated Using Electrospun Collagen-PCL Blends: Morphogenesis and Mechanical Properties." Tissue Engineering 15, no. 8, 2177 - 2187.

2008

  • Armour, A.D., Powell, H.M., Boyce, S.T., 2008, "Fluorescein Diacetate for Determination of Cell Viability in Tissue-Engineered Skin." Tissue Engineering Part C- Methods 14, no. 1, 89 - 96.
  • Powell, H.M., Supp, D.M., Boyce, S.T., 2008, "Influence of electrospun collagen on wound contraction of engineered skin substitutes." Biomaterials 29, no. 7, 834 - 843.
  • Powell,H,M, Boyce,S,T, 2008, "Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes." Journal of Biomedical Materials Research Part A 84A, no. 4, 1078 - 1086.

2007

  • Powell, H.M., Ayodeji O, Summerfield TL, Powell DM, Kniss DA, 2007, "Chemotherapeutic implants via subcritical CO2 modification." Biomaterials 28, no. 36, 5562 - 5569.
  • Kang, X., Y. Xie, H.M. Powell, L.J. Lee, M.A. Belury, J.J. Lannutti and D.A. Kniss, 2007, "Adipogenesis of Murine Embryonic Stem Cells in a Three-Dimensional Culture System Using Electrospun Polymer Scaffolds." Biomaterials 28, no. 3, 450 - 458.
  • Powell, H.M.,Boyce, S.T., 2007, "Wound closure with EDC cross-linked cultured skin substitutes grafted to athymic mice." Biomaterials 28, no. 6, 1084 - 1092.

2006

  • Powell, H.M, Kniss, D.A., Lannutti, J.J., 2006, "Nanotopographic Control of Cytoskeletal Organization." Langmuir 22, no. 11, 5087 - 5094.
  • Powell, H.M., Boyce, S.T., 2006, "EDC cross-linking improves skin substitute strength and stability." Biomaterials 27, no. 34, 5821 - 5827.

2004

  • Wang,Haibo; Lee,Jong-Kook; Moursi,Amr,M; Anderson,David; Winnard,Phillip; Powell,Heather; Lannutti,John, 2004, "Microstructural disassembly of calcium phosphates.." Journal of biomedical materials research. Part A 68, no. 1, 61 - 70.
  • Wang H, Lee JK, Moursi AM, Anderson D, Winnard P, Powell H, Lannutti J, 2004, "Microstructural disassembly of calcium phosphates." Journal of Biomedical Materials Research 68, no. 1, 61 - 70.
  • Wang, H., Lee, J.K., Moursi, A.M., Anderson, D., Winnard, P., Powell, H., Lannutti, J.J., 2004, "Microstructural disassembly of calcium phosphates." Journal of Biomedical Materials Research Part A 68A, no. 1, 61 - 70.

2003

  • Powell, H.M., Lannutti, J.J., 2003, "Nanofibrillar Surfaces Via Reactive Ion Etching." Langmuir 19, no. 21, 9071 - 9078.
  • Wood, I., Powell, H.M., Kohm, A., Lannutti, J.J., Dyce, J., 2003, "Evaluation of femoral head damage during canine total hip replacement: a comparison of four reduction techniques." Veterinary Comparative Orthopaedics and Traumatology 16, 184 - 190.

2002

  • Xie, Y., T. Sproule, Y. Li, H. Powell, JJ Lannutti, DA Kniss, 2002, "Nanoscale modifications of PET polymer surfaces via oxygen-plasma discharge yield minimal changes in attachment and growth of mammalian epithelial and mesenchymal cells in vitro." Journal of Biomedical Materials Research 61, no. 2, 234 - 245.

Unknown

  • Fischer, S.N., Weber, M.E., Baran, C.P., Willard, J.J., Johnson, J., Sanders, J.A., Ostrowski, M.C., Lannutti, J.J., Powell, H.M., Ghadiali, S., and C.B. Marsh, "The biostructural and biomechanical effects of eta-2 phosphorylation in pulmonary fibrosis." American Journal of Physiology - Lung Cellular and Molecular Physiology

Presentations

  • "Gene expression and protein production in electrospun skin substitutes cultured under static strain." 2008, Presented at Midwest Tissue Engineering Consortium, Cincinnati, US|USA
  • "Bioengineered Skin Substitutes Fabricated with Electrospun Decrease In Vivo Wound Contraction." 2007, Presented at Tissue Engineering and Regenerative Medicine Society International, Toronto, CA|CAN
  • "Culture Under Static Mechanical Load Improves Electrospun Skin Substitute Strength." 2007, Presented at Tissue Engineering and Regenerative Medicine International Society, Toronto, CA|CAN
  • "Soft Tissue Biomechanics." 2009, Presented at University of Cincinnati, Cincinnati,
  • "Engineering Biomimetic Skin Mechanics." 2009, Presented at Dorothy M. Davis Heart and Lung Research Institute Research in Progress, Columbus, US|USA
  • "Mechano-Modulation of Burn Wound Scarring." 2010, Presented at Center for Clinical and Translational Science Pilot Awardee Symposium, Columbus,
  • "Engineered Skin Biomechanics: Balancing Biology and Materials Science." 2010, Presented at Department of Mechanical Science Colloquium Series, Champaign, US|USA
  • "Composite Scaffolds for Skin Engineering." 2010, Presented at Heal Ohio Annual Meeting, Rootstown,
  • "Control of Engineered Coaxial Scaffold Strength Using Core Diameter." 2009, Presented at Biomedical Engineering Society Annual Meeting, Pittsburgh, US|USA
  • "Nanotopographic Control of Cytoskeletal Organization." 2005, Presented at Midwest Tissue Engineering Consortium, Cleveland, US|USA
  • "Uniaxial strain regulated morphogenesis, gene expression and tissue strength in engineered skin." 2009, Presented at Wound Healing Soceity and Society for Advancement of Wound Care Annual Meeting, Dallas, US|USA
  • "Stem Cells and Skin Tissue Engineering." 2009, Presented at Wound Healing and Hyperbaric Oxygen Symposium, Columbus, US|USA
  • "Somatic Stem Cells for Tissue Engineering." 2009, Presented at Stem Cell Interest Group Meeting, Columbus,
  • "Effect of Pore Size and Mechanical Stimulation on Stiffness and Col1 Gene Expression of Collagen-C6S Constructs." 2010, Presented at Orthopaedic Research Society Annual Meeting, New Orleans, US|USA
  • "Effect of Mechanical Stimulation on Construct Linear Stiffness for MSC-Collagen-Chondroitin-6-Sulfate Tissue Engineered Constructs." 2010, Presented at Midwest Tissue Engineering Consortium, Cleveland, US|USA
  • "Composite Scaffolds for Improved Engineered Skin Strength and Viability." 2010, Presented at Wound Healing Society and Society for the Advancement of Wound Care Annual Meeting, Orlando, US|USA
  • "Biomaterials as Drug Delivery Devices via Subcritical CO2 Modification." 2004, Presented at Society for Biomaterials World Congress, Sydney,
  • "Electrospun Tubular Scaffolds for Vascular Tissue Engineering." 2004, Presented at Society for Biomaterials World Congress, Sydney,
  • "EDC Crosslinking Improves Skin Substitute Strength and Stability." 2006, Presented at Tissue Engineering and Regenerative Medicine International Society World Congress, Pittsburgh, US|USA
  • "An Experiment-Simulation Approach to Determine Electrospun Fiber Properties." 2011, Presented at MS&T Fall National Meeting, Columbus,
  • "Geometric Deformation of Scaffolds as a Function of Scaffold Stiffness." 2011, Presented at TMS Spring Meeting, San Diego,
  • "Vascular Wall Engineering via Femtosecond Laser Processing." 2011, Presented at MS&T Fall National Meeting, Columbus,
  • "PCL-Gelatin Nanofibers for Extended Drug Release." 2011, Presented at MS&T Fall National Meeting, Columbus,
  • "Plasma Surface Modification of Electrospun Fibers for Adhesion-Based Cancer Cell Sorting." 2011, Presented at MS&T Fall National Meeting, Columbus,
  • "Mechanical and Molecular Strategies to Control Skin Mechanics." 2013, Presented at University of Minnesota, Big Ten BME Invited Lecture Series, Minneapolis,
  • "Fatigue Properties of Electrospun Tri-Layered Vascular Graft Scaffolds." 2013, Presented at BMES Annual Meeting, Seattle,
  • "Capturing the Local Mechanical Environment and Single Fiber Response in PCL Scaffolds." 2013, Presented at BMES Annual Meeting, Seattle,
  • "Myoferlin Depletion Increases Adhesion and Alters Adhesion Proteins in Breast Cancer Cells." 2013, Presented at BMES Annual Meeting, Seattle,
  • "Epidermal Differentiation Governs Engineered Skin Biomechanics." 2010, Presented at BMES Annual Meeting, Austin,
  • "Influence of Scaffold Hydration on Fiber Geometry and Extension." 2011, Presented at MS&T Fall National Meeting, Columbus,
  • "A Combined Computational-Experimental Approach to Improving Engineered Skin Biomechanics." 2012, Presented at 5th Annual Translational to Clinical Regenerative Medicine Wound Care Conference, Columbus,
  • "Biomaterial, Mechanical and Molecular Strategies to Control Skin Mechanics." 2013, Presented at University of Cincinnati, BME Seminar Series,
  • "Biomaterial, Mechanical and Molecular Strategies to Control Skin Mechanics." 2013, Presented at University of Akron, BME Department Seminar, Akron,
  • "Mechano-Modulation of Burn Wound Scarring." 2013, Presented at BMES Annual Meeting, Seattle,
  • "Computational Modeling and Mechanical Stimulation for Enhanced Bioengineered Skin Mechanics." 2013, Presented at BMES Annual Meeting, Seattle,
  • "Materials Development for Biomimetic Engineered Skin Mechanics." 2011, Presented at MS&T Fall National Meeting, Columbus,
  • "Engineered Skin: New Strategies for Biomechanical Mimicry." 2012, Presented at Mathematical Biosciences Institute Workshop on Tissue Engineering, Columbus,
  • "Skin Biomechanics: Role of miRNA and Mechano-Modulation." 2012, Presented at Shriners Hospitals for Children Research Seminar, Cincinnati,
  • "Computational Modeling and Scaffold Design in Regenerative Medicine." 2013, Presented at 6th Annual Translational to Clinical Regenerative Medicine Wound Care Conference, Columbus,

Papers in Proceedings

2009

  • Jain,A. Kinneberg,K.R.C., Nirmalanandhan,V.S., Shearn, J.T., Powell, H.M., Gooch, C., Butler,D.L. "Regulation of Tendone Tissue Engineered Construct Stiffness by Culture Time, Mesenchymal Stem Cells and Mechanical Stimulation." JOURNAL: "PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B." in ASME Summer Bioengineering Conference. (1 2009). 1203 - 1204.
  • Powell,Heather,M; McFarland,Kevin,L; Butler,David,L; Supp,Dorothy,M; Boyce,Steven,T "UNIAXIAL STRAIN REGULATES MORPHOGENESIS, GENE EXPRESSION AND TISSUE STRENGTH IN ENGINEERED SKIN." JOURNAL: "WOUND REPAIR AND REGENERATION." in Wound Healing Society Annual Meeting. (3 2009). A43 - A43.
  • Powell,Heather,M; McFarland,Kevin,L; Butler,David,L; Supp,Dorothy,M; Boyce,Steven,T "UNIAXIAL STRAIN REGULATES MORPHOGENESIS, GENE EXPRESSION AND TISSUE STRENGTH IN ENGINEERED SKIN." JOURNAL: "WOUND REPAIR AND REGENERATION." in Wound Healing Society Annual Meeting. (3 2009). A43 - A43.

2007

  • Nirmalanandhan, V.S., Kinneberg, K.R.C., Juncosa-Melvin, N., Powell, H.M., Rao, M., Boyce, S.T., Butler, D.L. "Evaluation of a novel scaffold material for tendon tissue engineering." JOURNAL: "PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007." in ASME Summer Bioengineering Conference. (1 2007). 1005 - 1006.
  • Nirmalanandhan, V.S., Kinneberg, K.R.C., Juncosa-Melvin, N., Powell, H.M., Rao, M., Boyce, S.T., Butler, D.L. "Evaluation of a novel scaffold material for tendon tissue engineering." in Proceeding of the ASME Summer Bioengineering Conference. (1 2007). 1005 - 1006.
  • Kinneberg, K.R.C., Nirmalanandhan,V.S., Powell, H.M., Boyce, S.T., Butler, D.L. "Combined effect of glycosaminoglycan and mechanical stimulation on the in vitro biomechanics of tissue engineered tendon constructs." JOURNAL: "PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007." in ASME Summer Bioengineering Conference. (1 2007). 1007 - 1008.

Patents

  • Powell, H.M., Sen, C.K., Roy, S.. "VacAid: New Generation Band-Aid for Wound Care."
  • Powell, H.M., Weirich T., Thomson, M.. "Device for Precise Delivery of Heat and Pressure for Burn Wound Generation."
  • Powell, H.M., Lannutti, J.J., Blackstone, B.N.. "Adhesion-Based Cancer Cell Sorting via Electrospun Fiber." Patent number: 61/620,630