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Jianjun Guan

  • Professor, Materials Science Engineering
  • 494 Watts Hall
    2041 College Rd
    Columbus, OH 43210
  • 614-292-9743

Honors

  • 20170601-20200501

    member of College of Reviewers.

  • 20170401

    Lumley Interdisciplinary Research Award.

  • 20160401

    Lumley Research Award.

  • 20110101

    Lumley Research Award.

Edited Books

2016

  • 22 book chapters,. 2016. "Advances in Polyurethane Biomaterials." Woodhead Publishing, an imprint of Elsevier.

Chapters

2016

  • 2016. "Interaction of cells with polyurethane scaffolds." In Advances in Polyurethane Biomaterials,
  • 2016. "Ultrastructure and Biomechanical Properties of the Skeletal Muscle ECM: Implications in Tissue Regeneration." In Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine,
  • 2016. "Myocardial Regenerative Medicine." In Polymeric Biomaterials for Tissue Regeneration From Surface/Interface Design to 3D Constructs, edited by Changyou Gao, ; Changyou Gao,,

2006

  • 2006. "Soft Tissue Scaffolds." In Wiley Encyclopedia of Biomedical Engineering, edited by Metin Akay,

2004

  • 2004. "Biodegradable Elastomers." In Encyclopedia of Biomaterials and Engineering,

Journal Articles

2018

  • Fan, Z.; Xu, Z.; Niu, H.; Gao, N. et al., 2018, "An Injectable Oxygen Release System to Augment Cell Survival and Promote Cardiac Repair Following Myocardial Infarction.." Sci Rep 8, no. 1, 1371 - 1371.

2017

  • McReynolds, J.; Wen, Y.; Li, X.; Guan, J. et al., 2017, "Modeling spatial distribution of oxygen in 3d culture of islet beta-cells.." Biotechnol Prog 33, no. 1, 221-228 - 221-228.

2016

  • Xu, Y.; Guan, J., 2016, "Biomaterial property-controlled stem cell fates for cardiac regeneration." Bioactive Materials 1, no. 1, 18-28 - 18-28.
  • Tamama, K.; McFadden, K.; Guan, J., 2016, "Improving Stem and Progenitor Cell Therapeutics.." Stem Cells Int 2016, 1409762-1409762 - 1409762-1409762.
  • Fan, Z.; Guan, J., 2016, "Antifibrotic therapies to control cardiac fibrosis.." Biomater Res 20, 13-13 - 13-13.
  • Li, X.; Tamama, K.; Xie, X.; Guan, J., 2016, "Improving Cell Engraftment in Cardiac Stem Cell Therapy.." Stem Cells Int 2016, 7168797-7168797 - 7168797-7168797.

2014

  • Xu Y, Patnaik S, Li Z, Lo W, Butler R, Claude A, L,, 2014, "Cardiac differentiation of cardiosphere-derived cells in scaffolds mimicking morphology of the cardiac extracellular matrix." Acta Biomater 10, no. 8, 3449-3462 - 3449-3462.
  • Li, Z.; Xu, Y.; Li, H.; Guan, J., 2014, "Immobilization of insulin-like growth factor-1 onto thermosensitive hydrogels to enhance cardiac progenitor cell survival and differentiation under ischemic conditions." Science China Chemistry 57, no. 4, 568-578 - 568-578.

2013

  • Feng Wang, ; Zhenqing Li, ; Jianjun Guan,, 2013, "Fabrication of Mesenchymal Stem Cells-Integrated Vascular Constructs Mimicking Multiple Properties of the Native Blood Vessels." Journal of Biomaterials Science – Polymer Edition 24, no. 7, 769-783 - 769-783.
  • Ryotaro Hashizume, Kazuro L. Fujimoto, Yi Hong, Ji,, 2013, "Biodegradable elastic patch plasty ameliorates left ventricular adverse remodeling after ischemia–reperfusion injury: A preclinical study of a porous polyurethane material in a porcine model." The Journal of Thoracic and Cardiovascular Surgery 146, no. 2, 391-399.e1 - 391-399.e1.

2012

  • Feng Wang, Hongyan He, Xinmei Wang, Zhenqing Li, Daniel Gallego-Perez, Jianjun Guan, L. James Lee, 2012, "Micropatterned Thermo-Responsive Surfaces by Polymerization of Monomer Crystals: Modulating Cellular Morphology and Cell-Substrate Interactions." Analytical Chemistry (IF 5.856) 84, no. 21, 9439-45 - 9439-45.
  • Christopher G Elliott, Jian Wang, Xiaolei Guo, Xu Shiwen, Mark Eastwood, Jianjun Guan,Andrew C Leask, Simon J Conway, and Douglas Hamilton, 2012, "Periostin modulates myofibroblast differentiation during full thickness cutaneous wound." Journal of Cell Science 125, no. 1, 121-132 - 121-132.

2011

  • Zhenqing Li, ; Jianjun Guan,, 2011, "Thermosensitive hydrogels for drug delivery." Expert Opinion on Drug Delivery 8, no. 8,
  • Zhenqing Li, Jianjun Guan*, 2011, "Hydrogels for Cardiac Tissue Engineering." Polymers 3, no. 2, 740-761 - 740-761.
  • Zhenqing Li, Xiaolei Guo, Satoshi Matsushita, Jianjun Guan*, 2011, "Cardiosphere-derived cells differentiation into a mature cardiac lineage using biodegradable poly(N-isopropylacrylamide) hydrogels." Biomaterials 32, no. 12, 3220-32 - 3220-32.
  • Jianjun Guan*, Feng Wang, Zhenqing Li, Joseph Chen, Xiaolei Guo, Jun Liao, Nicanor I. Moldovan, 2011, "The stimulation of the cardiac differentiation of mesenchymal stem cells in tissue constructs that mimic myocardium structure and biomechanics." Biomaterials 32, no. 24, 5568-5580 - 5568-5580.

2010

  • Feng Wang, ; Jianjun Guan,, 2010, "Cellular cardiomyoplasty and cardiac tissue engineering for myocardial therapy." Advanced Drug Delivery Reviews 62, no. 7-8,
  • Bo Wang, Ali Borazjani, Mina Tahai, Amy L. de Jongh Curry, Dan T. Simionescu, Jianjun Guan, Filip To, Steve H. Elder, Jun Liao, 2010, "Fabrication of cardiac patch with decellularized porcine myocardial scaffold and bone marrow mononuclear cells." Journal of Biomedical Materials Research 94A, no. 4, 1100-1110 - 1100-1110.
  • Feng Wang, Zhenqing Li, Mahmood Khan, Kenichi Tamama, Periannan Kuppusamy, William R. Wagner, Chandan K. Sen, Jianjun Guan, 2010, "Injectable, rapid gelling and highly flexible hydrogel composites as growth factor and cell carriers.." Acta Biomaterialia 6, no. 6, 1978-1991 - 1978-1991.

2006

  • Nieponice, Alejandro; Deasy, Bridget M.; Soletti, Lorenzo; Guan, Jianjun; Huard, Johnny; Wagner, William R.; Vorp, David A., 2006, "Characterization of muscle derived stem cells within a novel tissue engineered vascular graft." Tissue Engineering 12, no. 4, 1007 - 1007.

2004

  • John J. Stankus, Jianjun Guan, William R. Wagner, 2004, "Fabrication of biodegradable elastomeric scaffolds with sub-micron morphologies." Journal of Biomedical Materials Research 70A, no. 4, 603-614 - 603-614.

2003

  • Yabin Zhu, Changyou Gao, Jianjun Guan, Jiacong Shen, 2003, "Engineering porous polyurethane scaffolds by photografting polymerization of methacrylic acid for improved endothelial cell compatibility.." Journal of Biomedical Materials Research 67A, no. 4, 1367-1373 - 1367-1373.
  • Yi Hong, Changyou Gao, Jianjun Guan, Jiacong Shen, 2003, "Influence of quaternized polyurethane membrane surfaces on human endothelial cell attachment and growth.." Journal of Bioactive and Compatible Polymers 18, no. 3, 191-206 - 191-206.
  • Changyou Gao, Jianjun Guan, Yabin Zhu, Jiacong Shen, 2003, "Surface immobilization of bioactive molecules on polyurethane surface for promotion of cytocompatibility to human endothelial cells." Macromolecular Bioscience 3, no. 3-4, 157-162 - 157-162.

2002

  • Changyou Gao, Yuan Jun, Jianjun Guan, Jiacong Shen, 2002, "Immobilization of gelatin onto polyurethane membrane surface and acceleration of endothelial cells growth." CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 23, no. 6, 1210-1212 - 1210-1212.

2001

  • Changyou Gao, Jianjun Guan, Jiacong Shen, 2001, "Grafting of hydrophilic monomers onto polyurethane membranes by solution or pre-absorbing methods for acceleration of cell compatibility." CHINESE JOURNAL OF POLYMER SCIENCE 19, no. 5, 493-498 - 493-498.
  • Jianjun Guan, Changyou Gao, Jiacong Shen, 2001, "Preparation and characterization of cell compatible polyurethane." CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 22, no. 2, 317-320 - 317-320.
  • Changyou Gao, Xiaohong Hu, Jianjun Guan, Jiacong Shen, 2001, "Factors controlling the preparation of porous polyurethane membranes via thermally induced phase separation." ACTA POLYMERICA SINICA NA, no. 3, 351-356 - 351-356.
  • Jianjun Guan, Changyou Gao, Wenjun Yang, Jiacong Shen, 2001, "Self-crosslinking and cocrosslinking with nitrile rubber of poly(vinyl chloride) with pendent N,N-diethyldithiocarbamate group." JOURNAL OF APPLIED POLYMER SCIENCE 80, no. 4, 634-638 - 634-638.

2000

  • Jianjun Guan, Wenjun Yang, 2000, "Photo-graft polymerization of poly(vinyl chloride) containning N,N-diethyldithiocarbamate groups with vinyl monomers." JOURNAL OF APPLIED POLYMER SCIENCE 77, no. 12, 2569-2574 - 2569-2574.
  • Jianjun Guan, Changyou Gao, Linxian Feng, Jiacong Shen, 2000, "Functionalizing of polyurethane surfaces by photo-grafting with hydrophilic monomers." Journal of Applied Polymer Science 77, no. 11, 2505-2512 - 2505-2512.
  • Jianjun Guan, Changyou Gao, Linxian Feng, Jiacong Shen, 2000, "Preparation of functional poly(ether-urethane) for immobilization of human living cells 1: surface graft polymerization of poly(ether-urethane) with 2-(dimethylamino)ethyl methacrylate and quaternization of grafted membrane." EUROPEAN POLYMER JOURNAL 36, no. 12, 2707-2713 - 2707-2713.

1998

  • Jianjun Guan, Wenjun Yang, Yong Liu, Lifang Mei, 1998, "Synthesis and crosslinking reaction of crosslinkable PVC." CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 19, no. 1, 152-155 - 152-155.

1997

  • Wenjun Yang, Jianjun Guan, Shu Ye, Weiguo Cui, Jiacong Shen, 1997, "Enhanced irradiation self-crosslinking and co-crosslinking with nitrile rubber of poly(vinyl chloride) with pendent N,N-diethyldithiocarbamate groups." EUROPEAN POLYMER JOURNAL 33, no. 5, 761-765 - 761-765.

1996

  • Wenjun Yang, Jianjun Guan, Shu Ye, Weiguo Cui, Jiacong Shen, 1996, "Polymerization of MMA initiated by PVC with pendent N,N-diethyldithiocarbamate groups under UV-irradiation." CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 17, no. 9, 1473-1476 - 1473-1476.

Presentations

  • "The Stimulation of Stem Cell Differentiation into Cardiac Lineage Using Fibrous Scaffolds." 2012, Presented at International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration,
  • "Synthesis of poly(N-isopropylacrylamide) hydrogels to direct cardiac differentiation of stem cells.." 2011, Presented at 2011 American Chemical Society Fall Meeting,
  • "Stimulation of Cardiac Differentiation of Stem Cells Using Matrix Stiffness." 2012, Presented at University of Connecticut,
  • "Injectable, highly flexible and thermoresponsive hydrogels for mesenchymal stem cell proliferation and differentiation." 2010, Presented at 2010 American Chemical Society Fall Meeting,
  • "Differentiation of Cardiac Progenitor Cells Using Fibrous Scaffolds." 2012, Presented at 2012 AIChE annual meeting,
  • "Development of Elastic Scaffolds for Cardiovascular Tissue Engineering." 2008, Presented at Seminar at Department of Biomedical Engineering, Ohio State University,
  • "Development of Elastic Scaffolds for Cardiovascular Tissue Engineering." 2008, Presented at Research in Progress seminar at Davis Heart and Lung Research Institute, Ohio State University,
  • "Development of Biodegradable and Flexible Polymers for Cardiovascular Tissue Engineering." 2006, Presented at Seminar at Department of Polymer Science and Engineering, Zhejiang University, China,
  • "Development of Biodegradable and Elastomeric Scaffolds for Cardiovascular Tissue Engineering." 2007, Presented at Seminar at Department of Biomedical Engineering, University of Alabama at Birmingham,
  • "Development of Biodegradable and Elastomeric Scaffolds for Cardiovascular Tissue Engineering." 2006, Presented at Seminar at Histogenics Corporation,
  • "Development of Biodegradable and Elastomeric Scaffolds for Cardiovascular Tissue Engineering." 2006, Presented at Seminar at Department of Materials Science and Engineering, Ohio State University,
  • "Biomimetic Engineering of Microenvironment for Cardiovascular Tissue Engineering." 2009, Presented at Research in Progess Seminar at Davis Heart and Lung Research Institute, Ohio State University,
  • "Biomimetic Biomaterials for Cardiovascular Tissue Engineering." 2009, Presented at Seminar in Department of Materials Science and Engineering, Purdue University,
  • "Biodegradable and Flexible Scaffolds for Cardiovascular Tissue Engineering." 2007, Presented at 2007 Wound Healing Research Conference, McGowan Institute for Regenerative Medicine, University of Pittsburgh,
  • "Attenuation of cardiac fibrosis after myocardial infarction." 2017, Presented at Tissue Engineering and Regenerative Medicine International Society- Asia Pacific (TERMIS-AP) Meeting,
  • "Oxygen releasing stem cell delivery systems for ischemic limb regeneration." 2017, Presented at Seminar at School of Chemical and Biomedical Engineering, Nanyang Technological University (Singapore),
  • "Oxygen releasing stem cell delivery systems for ischemic limb regeneration." 2017, Presented at Seminar at Department of Polymer Science and Engineering, Shanghai Jiaotong University (SJTU),
  • "Multifunctional stem cell delivery systems for ischemic limb regeneration." 2016, Presented at Seminar at Department of Bioengineering, University of Texas-Arlington,
  • "Multifunctional stem cell delivery systems for ischemic limb regeneration." 2016, Presented at Seminar at College of Nanoscience and Engineering, SUNY Albany,
  • "Engineering biomaterials for cardiovascular and musculoskeletal tissue regeneration." 2016, Presented at International Forum of Biomedical Materials,
  • "Multifunctional hydrogels for musculoskeletal tissue regeneration." 2016, Presented at Seminar at Department of Materials Science and Engineering, China University of Petroleum (Beijing),
  • "Multifunctional hydrogels for cardiovascular tissue regeneration." 2016, Presented at Seminar at Department of Materials Science and Engineering, Zhejiang University of Technology,
  • "Injectable hydrogel-based stem cell delivery systems for ischemic limb regeneration." 2015, Presented at Seminar at Department of Biomedical Engineering, University of Akron,
  • "Multifunctional hydrogels for cardiovascular and musculoskeletal tissue regeneration." 2015, Presented at Seminar at Institute of Orthopedic Research, Soochow University, China,
  • "Multifunctional hydrogels for cardiovascular and musculoskeletal tissue regeneration." 2015, Presented at Seminar at Tongji Hospital, Tongji University,
  • "Multifunctional hydrogels for cardiovascular and musculoskeletal tissue regeneration." 2014, Presented at Seminar at Department of Polymer Science and Engineering, Zhejiang University,
  • "Plastics and elastomers for regenerative medicine." 2014, Presented at Make@OSU event, Center for Clinical and Translational Science, Ohio State University,
  • "Engineering prosurvival microenvironments to augment stem cell engraftment and differentiation in infarct hearts." 2013, Presented at Klassen Research Day, OSU Department of Surgery,
  • "Multifunctional hydrogels as stem cell carriers for cardiac cell therapy." 2013, Presented at Seminar at Department of Biomedical Engineering, University of Akron,
  • "Novel hydrogels to modulate stem cell behavior." 2013, Presented at Lubrizol LeARN seminar series, Lubrizol Brecksville site,

Papers in Proceedings

2011

  • Zhenqing Li, Xiaolei Guo, Jianjun Guan "Synthesis of Poly(N-isopropylacrylamide) Hydrogels to Direct Cardiac Differentiation of Stem Cells." in Polymer Preprint. (8 2011).

2010

  • Zhenqing Li, Jianjun Guan "Injectable, highly flexible and thermoresponsive hydrogels for mesenchymal stem cell proliferation and differentiation." in Polymer Preprints. (8 2010).
  • Chen, Joseph; Wang, Feng; Williams, Lakiesha; Guan, Jianjun; Liao, Jun "A Novel Trilayered Polymer Scaffold Mimicking Native Aortic Valve Leaflet." in Proceedings of the ASME Summer Bioengineering Conference. (6 2010).

2008

  • Hansong Zeng, Feng Wang, Jianjun Guan and Yi Zhao (2008). Microelectrodes-Assisted Micropatterning on Nanofiber. MRS Proceedings, 1138 , 1138-FF06-23 doi:10.1557/PROC-1138-FF06-23 "Microelectrodes-Assisted Micropatterning on Nanofiber." in MRS 2008 Meeting. (11 2008).

Unknown

  • Bo Wang, Robbin Bertucci, Zhenqing Li, Raj Prabhu, ; Guan, J.; Jun Liao, "Effect of thermosensitive hydrogel injection on mechanical behavior of porcine myocardium." in Proceedings of the ASME Summer Bioengineering Conference- 2013.

Patents

  • Kazuro L. Fujimoto, Kimimasa Tobita, Jianjun Guan, Bradley Keller, William R. Wagner. "Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions." Patent number: US8974542
  • Jianjun Guan, Kazuro L. Fujimoto, William Wagner. "Thermoresponsive, biodegradable, elastomeric material." Patent number: US8889791
  • "Thermoresponsive, biodegradable, elastomeric material and uses therefor." Patent number: US8673295
  • Stephen F. Badylak, Donald Freytes, Jianjun Guan, John Stankus, William R. Wagner, Thomas W. Gilbert. "Biohybrid elastomeric scaffolds." Patent number: US8535719
  • "Photo-oxidation graft process of preparing cell compatible biological material." Patent number: 1389480
  • Changyou Gao, Zuwei Ma, Jianjun Guan. "Photo-oxidation graft and bioactive factor immobilizing process of preparing cell compatible biological material." Patent number: 1389481
  • "Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions." Patent number: US8974542