MSE Special Seminar: Jinghua Li, Advanced Thin-Film Materials and Electronics for High-Resolution and Chronically Stable Neural Interfaces
The human body, such as the brain, produces a wide range of biophysical and biochemical signals that contain important information about the health condition and the progression of various diseases. There are critical challenges, however, to efficiently capture the signals due to the rigid characteristics of conventional medical systems. To address this issue, the design of thin, soft and flexible electronics forms the basis of novel wearable and implantable biomedical devices for the diagnostics and treatment of brain injuries and other chronic neurodegenerative diseases with improved outcomes and reduced costs.
This talk will focus on the science and engineering of thin-film materials for recording and stimulation in the nervous system to extend the frontier of human healthcare. I will first introduce the design and innovation of Si nanomembrane as interface to the brain for flexible micro-electrocorticographic (μECoG) arrays with multidecade lifetimes under physiological conditions. The technology enables flexible, actively multiplexed μECoG electrodes for recording and stimulation in nervous systems with chronic stability, high sensitivity, and unprecedented level of spatiotemporal resolution. The second part of the presentation will include a discussion on the design and manufacturing of stretchable epidermal electronics capable of continuously measuring high-quality electrophysiological information on skin surfaces, including electromyography (EMG) and electroencephalography (EEG) signals. Together, these materials and electronics provide a realistic pathway to biomedical devices with biocompatibility, bioconformality and biostability for the applications in closed-loop neuromodulation and neuroscience research.
Jinghua Li is a postdoctoral researcher working with Prof. John A. Rogers in the Department of Materials Science and Engineering at Northwestern University. She received her Ph.D. degree in Chemistry from Duke University under the supervision of Prof. Jie Liu. Currently, she is working on the chemistry, design, manufacturing and integration of thin-film materials and bio-integrated electronics as neural interfaces for advanced healthcare. Dr. Li is a recipient of the 2014 Chinese Government Award for Outstanding Self-financed Students Abroad.